Mechanisms of Vascular Smooth Muscle Cell Migration
نویسندگان
چکیده
منابع مشابه
Mechanisms of vascular smooth muscle cell migration.
Smooth muscle cell migration occurs during vascular development, in response to vascular injury, and during atherogenesis. Many proximal signals and signal transduction pathways activated during migration have been identified, as well as components of the cellular machinery that affect cell movement. In this review, a summary of promigratory and antimigratory molecules belonging to diverse chem...
متن کاملRapamycin inhibits vascular smooth muscle cell migration.
Abnormal vascular smooth muscle cell (SMC) proliferation and migration contribute to the development of restenosis after percutaneous transluminal coronary angioplasty and accelerated arteriopathy after cardiac transplantation. Previously, we reported that the macrolide antibiotic rapamycin, but not the related compound FK506, inhibits both human and rat aortic SMC proliferation in vitro by inh...
متن کاملMechanisms of hepatocyte growth factor-mediated vascular smooth muscle cell migration.
The migration of vascular smooth muscle cells (SMCs) from the media into the neointima and their subsequent proliferation is important in the pathogenesis of atherosclerosis. This process is regulated by multiple factors, including growth factors, and involves changes in the interaction of SMCs with the extracellular matrix and in intracellular signaling cascades that regulate cell movement. We...
متن کاملPutting the brakes on vascular smooth muscle cell migration.
THE ABILITY OF AN ANIMAL CELL to move is essential for life. Cell locomotion occurs during development, in response to injury, and during regeneration and/or remodeling of existing tissue. It also occurs under pathological conditions, examples being cancer cell metastasis and cardiac hypertrophy and angiogenesis. Clearly, cell motility is a complex process involving many different systems, incl...
متن کاملTannin extracted from Sumac inhibits vascular smooth muscle cell migration
BACKGROUND Vascular smooth muscle cell (VSMC) migration is integral in the pathogenesis of atherosclerosis. Sumac (Rhus coriaria) berries are believed to have atheroprotective effects. Therefore, Sumac, which is a rich source of tannin antioxidants, was tested for its capacity to inhibit VSMC migratory activity. MATERIALS & METHODS Tannin was extracted and purified from ground Sumac. Cultured...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Circulation Research
سال: 2007
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.0000258492.96097.47